Journal article
The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice
eLife, v 11
27 Apr 2022
PMID: 35476640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Speed-dependent interlimb coordination allows animals to maintain stable locomotion under different circumstances. The V3 neurons are known to be involved in interlimb coordination. We previously modeled the locomotor spinal circuitry controlling interlimb coordination (Danner et al., 2017). This model included the local V3 neurons that mediate mutual excitation between left and right rhythm generators (RGs). Here, our focus was on V3 neurons involved in ascending long propriospinal interactions (aLPNs). Using retrograde tracing, we revealed a subpopulation of lumbar V3 aLPNs with contralateral cervical projections. V3
mice, in which all V3 neurons were silenced, had a significantly reduced maximal locomotor speed, were unable to move using stable trot, gallop, or bound, and predominantly used a lateral-sequence walk. To reproduce this data and understand the functional roles of V3 aLPNs, we extended our previous model by incorporating diagonal V3 aLPNs mediating inputs from each lumbar RG to the contralateral cervical RG. The extended model reproduces our experimental results and suggests that locally projecting V3 neurons, mediating left-right interactions within lumbar and cervical cords, promote left-right synchronization necessary for gallop and bound, whereas the V3 aLPNs promote synchronization between diagonal fore and hind RGs necessary for trot. The model proposes the organization of spinal circuits available for future experimental testing.
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Details
- Title
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice
- Creators
- Han Zhang - Dalhousie UniversityNatalia A Shevtsova - Drexel UniversityDylan Deska-Gauthier - Dalhousie UniversityColin Mackay - Dalhousie UniversityKimberly J Dougherty - Drexel UniversitySimon M Danner - Drexel UniversityYing Zhang - Dalhousie UniversityIlya A Rybak - Drexel University
- Publication Details
- eLife, v 11
- Publisher
- eLife
- Grant note
- R01 NS115900 / NINDS NIH HHS PJT-173547 / CIHR R01 NS104194 / NINDS NIH HHS R01 NS112304 / NINDS NIH HHS R01 NS110550 / NINDS NIH HHS MOP110950 / CIHR R21 NS118226 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000808592000001
- Scopus ID
- 2-s2.0-85128949571
- Other Identifier
- 991019167791204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology