Journal article
The role of annexin II in angiogenesis and tumor progression: A potential therapeutic target
Current pharmaceutical design, v 13(35), pp 3568-3575
01 Jan 2007
PMID: 18220793
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is well established that human tumors overproduce plasmin a serine protease that is known to promote angiogenesis, tumor growth and metastasis. However, the mechanism by which endothelial or tumor cells regulate the proteolytic activity of plasmin is not well understood. Cell surface receptors regulate activation of plasminogen to plasmin and its proteolytic activity. Annexin II is one of the well studied receptors for plasminogen and tPA, which binds to plasminogen and converts it to plasmin. Plasmin is a highly reactive enzyme which is physiologically involved in fibrinolysis. Since the proteolytic activity of plasmin is very tightly regulated, uncontrolled production of plasmin can degrade extracelluar matrix (ECM) and basement membrane (BM) of the surrounding blood vessels. Thus plasmin plays an important role in neoangiogenesis and cancer invasion and metastasis. Therefore, the receptor which regulates plasmin generation may be an attractive target for the development of anti-cancer/anti-metastatic agents. Angiostatin (AS), internal fragment of plasminogen, has been reported to inhibit human tumor growth and metastasis. We have shown that AS binds to endothelial/cancer cell surface annexin II with high affinity and interferes with plasmin generation suggesting that the role of plasmin/plasminogen system may be more complex than we previously thought. In this review we provide a comprehensive analysis of the literature in context of the role of annexin II in angiogenesis, tumor progression and metastasis. Compelling evidence from the literature and our own findings suggest that annexin II may be a potential target for the development of effective therapeutic strategies for the treatment of cancer and its induced metastasis.
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Details
- Title
- The role of annexin II in angiogenesis and tumor progression: A potential therapeutic target
- Creators
- Mahesh C. Sharma - Drexel UniversityMeena Sharma - Univ Penn, Philadelphia, PA 19104 USA
- Publication Details
- Current pharmaceutical design, v 13(35), pp 3568-3575
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000253583700004
- Scopus ID
- 2-s2.0-36949012954
- Other Identifier
- 991019168065804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy