Journal article
The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease
Neuroscience and biobehavioral reviews, v 156, pp 105476-105476
Jan 2024
PMID: 38029609
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Understanding perturbations in synaptic function between health and disease states is crucial to the treatment of neuropsychiatric illness. While genome-wide association studies have identified several genetic loci implicated in synaptic dysfunction in disorders such as autism and schizophrenia, many have not been rigorously characterized. Here, we highlight immunoglobulin superfamily member 9b (IgSF9b), a cell adhesion molecule thought to localize exclusively to inhibitory synapses in the brain. While both pre-clinical and clinical studies suggest its association with psychiatric diseases, our understanding of IgSF9b in synaptic maintenance, neural circuits, and behavioral phenotypes remains rudimentary. Moreover, these functions wield undiscovered influences on neurodevelopment. This review evaluates current literature and publicly available gene expression databases to explore the implications of IgSF9b dysfunction in rodents and humans. Through a focused analysis of one high-risk gene locus, we identify areas requiring further investigation and unearth clues related to broader mechanisms contributing to the synaptic etiology of psychiatric disorders.
Metrics
Details
- Title
- The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease
- Creators
- Jacob D Clarin - Drexel UniversityNatasha Reddy - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, United StatesCassandra Alexandropoulos - Drexel UniversityWen-Jun Gao - Drexel University
- Publication Details
- Neuroscience and biobehavioral reviews, v 156, pp 105476-105476
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001127707900001
- Scopus ID
- 2-s2.0-85178451217
- Other Identifier
- 991021811642404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences