Journal article
The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity
npj Biological Physics and Mechanics, v 2(1), 21
03 Sep 2025
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Abstract
While migratory cells can quickly change their mode of migration in complex three-dimensional environments, it is not clear why. Understanding the dynamic and reciprocal relationship migrating cells have with their microenvironments may help reveal why migratory plasticity, or mode-switching, is a common feature of eukaryotic cell motility. In this review, we discuss the physical and mechanical properties of cells and the environments they move through, and how those properties can influence each other. Given the dual role of the cytoskeleton in cell migration and cellular mechanics, we suggest that migratory plasticity derives from the necessity for the cell to maintain mechanical homeostasis in diverse physical environments.
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Details
- Title
- The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity
- Creators
- Jacob J. Duggan - Drexel UniversityRyan J. Petrie (Corresponding Author) - Drexel University
- Publication Details
- npj Biological Physics and Mechanics, v 2(1), 21
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Other Identifier
- 991022087656804721