Journal article
The role of estrogens in the adipose tissue milieu
Annals of the New York Academy of Sciences, v 1461(1), pp 127-143
Feb 2020
PMID: 31868931
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
One of the leading causes for the development of adverse metabolic effects, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body weight, often measured by body mass index (BMI). Although BMI, calculated using weight and height, is the standard measure used to determine body adiposity in clinical and public health guidelines, an inherent limitation is that BMI does not distinguish where in the body adiposity is deposited. Central obesity, characterized by greater accumulation of adiposity in the abdominal region, has been associated with a higher risk of mortality, independent of BMI. Importantly, one of the determinants of body fat distribution is sex hormones. Both estrogens and androgens appear to directly and indirectly influence body fat distribution. Our review will focus specifically on the role of estrogens and their influence in determining body fat distribution and overall health of adipose tissues, and the role of epigenetic mechanisms in regulating the production and function of estrogens.
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Details
- Title
- The role of estrogens in the adipose tissue milieu
- Creators
- John R Bracht - American UniversityVictoria J Vieira-Potter - University of MissouriRoberta De Souza Santos - Cedars-Sinai Medical CenterOrhan K Öz - The University of Texas Southwestern Medical CenterBiff F Palmer - The University of Texas Southwestern Medical CenterDeborah J Clegg - Drexel University
- Publication Details
- Annals of the New York Academy of Sciences, v 1461(1), pp 127-143
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000503893300001
- Scopus ID
- 2-s2.0-85079023040
- Other Identifier
- 991019357776704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism