Journal article
The role of genotypes that modify the toxicity of chemical mutagens in the risk for myeloproliferative neoplasms
International journal of environmental research and public health, v 12(3), pp 2465-2485
24 Feb 2015
PMID: 25719551
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The etiology of myeloproliferative neoplasms (MPN) (polycythemia vera; essential thrombocythemia; primary myelofibrosis) is unknown, however they are associated with a somatic mutation--JAK2 V617F--suggesting a potential role for environmental mutagens.
We conducted a population-based case-control study in three rural Pennsylvania counties of persons born 1921-1968 and residing in the area between 2000-2008. Twenty seven MPN cases and 292 controls were recruited through random digit dialing. Subjects were genotyped and odds ratios estimated for a select set of polymorphisms in environmentally sensitive genes that might implicate specific environmental mutagens if found to be associated with a disease.
The presence of NAT2 slow acetylator genotype, and CYP1A2, GSTA1, and GSTM3 variants were associated with an average 3-5 fold increased risk.
Exposures, such as to aromatic compounds, whose toxicity is modified by genotypes associated with outcome in our analysis may play a role in the environmental etiology of MPNs.
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Details
- Title
- The role of genotypes that modify the toxicity of chemical mutagens in the risk for myeloproliferative neoplasms
- Creators
- Carol Ann Gross-Davis - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA 19104, USA. gross-davis.carolann@epa.govKaryn Heavner - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA 19104, USA. karynkh@aol.comArthur L Frank - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA 19104, USA. alf26@drexel.eduCraig Newschaffer - Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA. cnewscha@drexel.eduJudith Klotz - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA 19104, USA. judith.klotz@comcast.netRegina M Santella - Department of Environmental Health Services, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. rps1@cumc.columbia.eduIgor Burstyn - Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA. cnewscha@drexel.edu
- Publication Details
- International journal of environmental research and public health, v 12(3), pp 2465-2485
- Publisher
- MDPI; Switzerland
- Grant note
- EH09-006E / NCEH CDC HHS ES009089 / NIEHS NIH HHS P30 ES009089 / NIEHS NIH HHS 1R01EH000640-01 / NCEH CDC HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000351929700009
- Scopus ID
- 2-s2.0-84927619441
- Other Identifier
- 991014878129004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health