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The role of lipid-lowering therapy in preventing coronary heart disease in patients with type 2 diabetes
Journal article   Open access   Peer reviewed

The role of lipid-lowering therapy in preventing coronary heart disease in patients with type 2 diabetes

Dean G Karalis
Clinical cardiology (Mahwah, N.J.), v 31(6)
Jun 2008
PMID: 17847038
url
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.20226View
Published, Version of Record (VoR) Open
url
https://doi.org/10.1002/clc.20226View
Published, Version of Record (VoR) Open

Abstract

Coronary Disease - blood Coronary Disease - etiology Coronary Disease - prevention & control Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - drug therapy Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypolipidemic Agents - therapeutic use Lipids - blood Treatment Outcome
Coronary heart disease is the most common cause of death among diabetic patients. The increased risk of coronary heart disease in type 2 diabetes is due, in part, to lipid abnormalities often present in the diabetic patient. Diabetic dyslipidemia is characterized by elevated triglycerides, low high-density lipoprotein cholesterol (HDL-C) and an increased preponderance of small, dense low-density lipoprotein cholesterol (LDL-C) particles. Current guidelines for the prevention of coronary heart disease in diabetic patients identify elevated LDL-C as the primary target of lipid-lowering therapy, and recommend statins as the first-line treatment for diabetic dyslipidemia. This review evaluates the large statin trials that have included diabetic patients, and discusses the role of combination therapy in managing dyslipidemia in diabetic patients.

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20 citations in Scopus

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Web of Science research areas
Cardiac & Cardiovascular Systems
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