Journal article
The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease
Journal of neuroscience research, v 102(1), pp e25261-n/a
Jan 2024
PMID: 38284858
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.
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Details
- Title
- The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease
- Creators
- Toufik Abdul-Rahman - Sumy State UniversityShankhaneel Ghosh - Institute of Medical Sciences and Sum HospitalJacob B Kalmanovich - Drexel UniversityAndrew Wireko Awuah - Sumy State UniversityMarija Zivcevska - Liberty UniversitySamar Khalifa - Kafrelsheikh UniversityEsther Edet Bassey - University of UyoNamarig Alnil Ali - Helwan UniversityMatheus Mendes Dos Santos Ferreira - Faculty of Medicine, Centro Universitário FIPMoc, Montes Claros, BrazilTungki Pratama Umar - London Centre for NanotechnologyNeil Garg - Rowan UniversityVictor Nnanna Nweze - Ghent UniversityVenkata Sai Sulekhya Inturu - Mamata Medical CollegeMaya Magdy Abdelwahab - Helwan UniversitySneha Kurian - Christian Medical CollegeAthanasios Alexiou - College Station Medical CenterMohammed Alfaleh - King Abdulaziz UniversityThamer M A Alqurashi - King Abdulaziz UniversityGhulam Md Ashraf - University of Sharjah
- Publication Details
- Journal of neuroscience research, v 102(1), pp e25261-n/a
- Publisher
- Wiley
- Grant note
- IFPDP-56-22 / King Abdulaziz University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001153553100006
- Scopus ID
- 2-s2.0-85177854057
- Other Identifier
- 991021901515504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences