Journal article
The role of neuron death in the development of the gender difference in the number of neurons in the rat superior cervical ganglion
International journal of developmental neuroscience, v 5(4), pp 305-311
1987
PMID: 3503506
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adult male rats have more neurons in their superior cervical ganglia than do adult females. This difference arises over the first two postnatal weeks, and is apparently related to perinatal levels of circulating testosterone. Exposure of neonatal rats to testosterone or estradiol during the first postnatal weeks results in an increase in the number of neurons in the superior cervical ganglion seen at 15, 30 or 60 days postnatally. The present studies were undertaken to determine whether this observed increase in neurons is due to an increase in neuronal proliferation or to a decrease in neuronal death. Results of autoradiographic studies show no evidence of enhanced neuronal proliferation following postnatal exposure to estradiol, but do show an increased survival of a prenatally labeled population of cells. Counts of degenerating cells in the superior cervical ganglion show that during the peak period of normal neuronal degeneration, on postnatal day 5, 17-beta-estradiol or testosterone propionate treated animals have significantly fewer degenerating superior cervical ganglion cells than do vehicle-injected littermate controls. In addition, vehicle-injected females have more degenerating cells on day 5 than do vehicle-injected males. Taken together these results provide strong evidence that the increase in superior cervical ganglion neurons seen after neonatal exposure to estradiol results from a reduction in developmental neuron death.
Metrics
Details
- Title
- The role of neuron death in the development of the gender difference in the number of neurons in the rat superior cervical ganglion
- Creators
- L L Wright - Boston UniversityA J Smolen - Drexel University
- Publication Details
- International journal of developmental neuroscience, v 5(4), pp 305-311
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- NS21577 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1987K863600004
- Scopus ID
- 2-s2.0-0023465580
- Other Identifier
- 991019183936204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology
- Neurosciences