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The roles of cohesins in mitosis, meiosis, and human health and disease
Journal article   Open access

The roles of cohesins in mitosis, meiosis, and human health and disease

Amanda S Brooker and Karen M Berkowitz
Methods in molecular biology (Clifton, N.J.), v 1170, pp 229-266
2014
DOI: https://doi.org/10.1007/978-1-4939-0888-2_11
PMID: 24906316
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4495907View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

alpha-Thalassemia - genetics alpha-Thalassemia - metabolism alpha-Thalassemia - pathology Animals Cell Cycle Proteins - analysis Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatids - genetics Chromatids - metabolism Chromosomal Proteins, Non-Histone - analysis Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation Craniofacial Abnormalities - genetics Craniofacial Abnormalities - metabolism Craniofacial Abnormalities - pathology De Lange Syndrome - genetics De Lange Syndrome - metabolism De Lange Syndrome - pathology Ectromelia - genetics Ectromelia - metabolism Ectromelia - pathology Humans Hypertelorism - genetics Hypertelorism - metabolism Hypertelorism - pathology Meiosis Mental Retardation, X-Linked - genetics Mental Retardation, X-Linked - metabolism Mental Retardation, X-Linked - pathology Mitosis
Mitosis and meiosis are essential processes that occur during development. Throughout these processes, cohesion is required to keep the sister chromatids together until their separation at anaphase. Cohesion is created by multiprotein subunit complexes called cohesins. Although the subunits differ slightly in mitosis and meiosis, the canonical cohesin complex is composed of four subunits that are quite diverse. The cohesin complexes are also important for DNA repair, gene expression, development, and genome integrity. Here we provide an overview of the roles of cohesins during these different events as well as their roles in human health and disease, including the cohesinopathies. Although the exact roles and mechanisms of these proteins are still being elucidated, this review serves as a guide for the current knowledge of cohesins.

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62 citations in Web of Science
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Web of Science research areas
Biochemical Research Methods
Biochemistry & Molecular Biology
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