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Journal article
The site and stage of anti-DNA B-cell deletion
Nature (London), v 373(6511)
19 Jan 1995
PMID: 7816141
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antibodies to DNA and nucleoproteins are found in sera of individuals with systemic autoimmune disease. In the population (and in the autoimmune mouse strain MRL/lpr) there is a great variety of such antinuclear antibodies, but individuals with systemic lupus erythematosus or single MRL mice express a subset only of the antinuclear specificities found in the population. These observations have been interpreted to mean that these antibodies arise by immunization. The oligoclonal nature of the autoantibody response and the evidence of selection acting on somatically mutated autoantibodies favour this interpretation. Specific activation of autoantibodies in disease implies either that autoantibodies are regulated in non-diseased individuals or that autoantigen availability is variable. The former has been demonstrated in anti-DNA transgenic mice. In normal mice, transgene-encoded antibodies against double-stranded (ds) DNA are not expressed in serum or on B cells. Here we describe modified anti-dsDNA transgenic mice which allow us to study the site and developmental stage at which such B-cell regulation occurs. This model shows that in normal mice B cells expressing anti-DNA specificity are deleted in the bone marrow at a pre-B to immature B transitional stage.
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Details
- Title
- The site and stage of anti-DNA B-cell deletion
- Creators
- Ching Chen - Princeton UniversityZoltan Nagy - Princeton UniversityMarko Radic - Drexel UniversityRichard Hardy - Fox Chase Cancer CenterChaomei Chen - Information Science (Informatics)
- Publication Details
- Nature (London), v 373(6511)
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science
- Web of Science ID
- WOS:A1995QC27800066
- Scopus ID
- 2-s2.0-0028850944
- Other Identifier
- 991019183982104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology