Journal article
The treatment effectiveness project. A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan
General hospital psychiatry, v 21(4), pp 260-273
01 Jul 1999
PMID: 10514950
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patients. Patients were recruited from a variety of primary care practice settings in four separate geographic locations (Hanover, New Hampshire; Pittsburgh, Pennsylvania; San Antonio, Texas; and Seattle, Washington). Patients were randomly assigned to each of the three intervention conditions; the medication/placebo conditions were double-blinded. The treatment trial was 11 weeks, with independent assessments of patient clinical status at baseline, 6 weeks, and 11 weeks. There was a follow-up at 25 weeks. Since there are relatively few placebo-controlled trials in primary care settings on patients with these disorders, the background of this project and a description of it are presented at this time, prior to the availability of outcome data, to provide methodological detail and to increase awareness in the research community of this treatment trial, with results to appear subsequently.
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Details
- Title
- The treatment effectiveness project. A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan
- Creators
- James E Barrett - Dartmouth CollegeJohn W Williams - Audie Murphy Memorial Veterans Hospital, University of Texas Science Center at San Antonio, San Antonio, Texas, USA (J.W.W.)Thomas E Oxman - Dartmouth CollegeWayne Katon - University of WashingtonEllen Frank - University of PittsburghMark T Hegel - Dartmouth CollegeMark Sullivan - University of WashingtonHerbert C Schulberg - University of Pittsburgh
- Publication Details
- General hospital psychiatry, v 21(4), pp 260-273
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000082767600006
- Scopus ID
- 2-s2.0-0032850022
- Other Identifier
- 991020836489504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry