Journal article
The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic
Progress in neurobiology, v 221, pp 102396-102396
Feb 2023
PMID: 36563928
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sharp-wave ripples, prominently in the CA1 region of the hippocampus, are short oscillatory events accompanied by bursts of neural firing. Ripples and associated hippocampal place cell sequences communicate with cortical ensembles during slow-wave sleep, which has been shown to be critical for systems consolidation of episodic memories. This consolidation is not limited to a newly formed memory trace; instead, ripples appear to reactivate and consolidate memories spanning various experiences. Despite this broad spanning influence, ripples remain capable of producing precise memories. The underlying mechanisms that enable ripples to consolidate memories broadly and with specificity across experiences remain unknown. In this review, we discuss data that uncovers circuit-level processes that generate ripples and influence their characteristics during consolidation. Based on current knowledge, we propose that memory emerges from the integration of two parallel consolidation pathways in CA1: the rigid and plastic pathways. The rigid pathway generates ripples stochastically, providing a backbone upon which dynamic plastic pathway inputs carrying novel information are integrated.
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Details
- Title
- The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic
- Creators
- Arron F Hall - Drexel UniversityDong V Wang - Drexel University
- Publication Details
- Progress in neurobiology, v 221, pp 102396-102396
- Publisher
- Elsevier
- Grant note
- R01 MH119102 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000909163000001
- Scopus ID
- 2-s2.0-85144579872
- Other Identifier
- 991020099162404721
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- Web of Science research areas
- Neurosciences