Journal article
The use of clinical parameters to predict obstructive sleep apnea syndrome severity in children: the Childhood Adenotonsillectomy (CHAT) study randomized clinical trial
JAMA otolaryngology-- head & neck surgery, v 141(2), pp 130-136
01 Feb 2015
PMID: 25474490
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is important to distinguish children with different levels of severity of obstructive sleep apnea syndrome (OSAS) preoperatively using clinical parameters. This can identify children who most need polysomnography (PSG) prior to adenotonsillectomy (AT).
To assess whether a combination of factors, including demographics, physical examination findings, and caregiver reports from questionnaires, can predict different levels of OSAS severity in children.
Baseline data from 453 children from the Childhood Adenotonsillectomy (CHAT) study were analyzed. Children 5.0 to 9.9 years of age with PSG-diagnosed OSAS, who were considered candidates for AT, were included.
Polysomnography for diagnosis of OSAS.
Linear or logistic regression models were fitted to identify which demographic, clinical, and caregiver reports were significantly associated with the apnea hypopnea index (AHI) and oxygen desaturation index (ODI).
Race (African American), obesity (body mass index z score > 2), and the Pediatric Sleep Questionnaire (PSQ) total score were associated with higher levels of AHI and ODI (P = .05). A multivariable model that included the most significant variables explained less than 3% of the variance in OSAS severity as measured by PSG outcomes. Tonsillar size and Friedman palate position were not associated with increased AHI or ODI. Models that tested for potential effect modification by race or obesity showed no evidence of interactions with any clinical measure, AHI, or ODI (P > .20 for all comparisons).
This study of more than 450 children with OSAS identifies a number of clinical parameters that are associated with OSAS severity. However, information on demographics, physical findings, and questionnaire responses does not robustly discriminate different levels of OSAS severity.
clinicaltrials.gov Identifier: NCT00560859.
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Details
- Title
- The use of clinical parameters to predict obstructive sleep apnea syndrome severity in children: the Childhood Adenotonsillectomy (CHAT) study randomized clinical trial
- Creators
- Ron B Mitchell - The University of Texas Southwestern Medical CenterSuzan Garetz - University of MichiganReneé H Moore - North Carolina State UniversityCarol L Rosen - Rainbow Babies & Children's HospitalCarole L Marcus - Children's Hospital of PhiladelphiaEliot S Katz - Boston Children's HospitalRaanan Arens - Children's Hospital at MontefioreRonald D Chervin - University of MichiganShalini Paruthi - Cardinal Glennon Children’s Medical CenterRaouf Amin - Cincinnati Children's Hospital Medical CenterLisa Elden - Cincinnati Children's Hospital Medical CenterSusan S Ellenberg - University of PennsylvaniaSusan Redline - Beth Israel Deaconess Medical Center
- Publication Details
- JAMA otolaryngology-- head & neck surgery, v 141(2), pp 130-136
- Publisher
- American Medical Association
- Grant note
- U01 HL083075 / NHLBI NIH HHS UL1 RR024989 / NCRR NIH HHS U01 HL083129 / NHLBI NIH HHS UL1 TR000439 / NCATS NIH HHS UL1 RR024134 / NCRR NIH HHS HL083075 / NHLBI NIH HHS UL1 TR000170 / NCATS NIH HHS HL083129 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000351583600006
- Scopus ID
- 2-s2.0-84923287717
- Other Identifier
- 991021448156104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology
- Surgery