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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The use of the orbitofrontal H-sulcus as a reference frame for value signals
The European journal of neuroscience, v 51(9), pp 1928-1943
May 2020
PMID: 31605399
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Understanding the factors that drive organization and function of the brain is an enduring question in neuroscience. Using functional magnetic resonance imaging (fMRI), structure and function have been mapped in primary sensory cortices based on knowledge of the organizational principles that likely drive a given region (e.g., aspects of visual form in primary visual cortex and sound frequency in primary auditory cortex) and knowledge of underlying cytoarchitecture. The organizing principles of higher-order brain areas that encode more complex signals, such as the orbitofrontal cortex (OFC), are less well understood. One fundamental component that underlies the many functions of the OFC is the ability to compute the reward or value of a given object. There is evidence of variability in the spatial location of responses to specific categories of objects (or value of said objects) within the OFC, and several reference frames have been proposed to explain this variability, including topographic spatial gradients that correspond to axes of primary versus secondary rewards and positive versus negative reinforcers. One potentially useful structural morphometric reference frame in the OFC is the "H-sulcus," a pattern formed by medial orbital, lateral orbital and transverse orbital sulci. In 48 human subjects, we use a structural morphometric tracing procedure to localize functional activation along the H-sulcus for face and food stimuli. We report the novel finding that food-selective responses are consistently found within the caudal portion of the medial orbital sulcus, but no consistency within the H-sulcus for response to face stimuli. These results suggest that sulcogyral anatomy of the H-sulcus may be an important morphological metric that contributes to the organizing principles of the OFC response to certain stimulus categories, including food.
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Details
- Title
- The use of the orbitofrontal H-sulcus as a reference frame for value signals
- Creators
- Vanessa Troiani - Autism & Developmental Medicine InstituteMarisa A. Patti - Autism & Developmental Medicine InstituteKayleigh Adamson - Autism & Developmental Medicine Institute
- Publication Details
- The European journal of neuroscience, v 51(9), pp 1928-1943
- Publisher
- Wiley
- Number of pages
- 16
- Grant note
- DA044015 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) Geisinger Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000493756900001
- Scopus ID
- 2-s2.0-85074566665
- Other Identifier
- 991022005185204721
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- Web of Science research areas
- Neurosciences