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Journal article
The yeast retrograde response as a model of intracellular signaling of rnitochondrial dysfunction
Frontiers in physiology, v 3, 139
01 Jan 2012
PMID: 22629248
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mitochondrial dysfunction activates intracellular signaling pathways that impact yeast longevity, and the best known of these pathways is the retrograde response. More recently, similar responses have been discerned in other systems, from invertebrates to human cells. However, the identity of the signal transducers is either unknown or apparently diverse, contrasting with the well-established signaling module of the yeast retrograde response. On the other hand, it has become equally clear that several other pathways and processes interact with the retrograde response, embedding it in a network responsive to a variety of cellular states. An examination of this network supports the notion that the master regulator NF kappa B aggregated a variety of mitochondria-related cellular responses at some point in evolution and has become the retrograde transcription factor. This has significant consequences for how we view some of the deficits associated with aging, such as inflammation. The support for NF kappa B as the retrograde response transcription factor is not only based on functional analyses. It is bolstered by the fact that NF kappa B can regulate Myc-Max, which is activated in human cells with dysfunctional mitochondria and impacts cellular metabolism. Myc-Max is homologous to the yeast retrograde response transcription factor Rtg1-Rtg3. Further research will be needed to disentangle the pro-aging from the anti-aging effects of NF kappa B. Interestingly, this is also a challenge for the complete understanding of the yeast retrograde response.
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Details
- Title
- The yeast retrograde response as a model of intracellular signaling of rnitochondrial dysfunction
- Creators
- S. Michal Jazwinski - Tulane UniversityAndres Kriete - Drexel University
- Publication Details
- Frontiers in physiology, v 3, 139
- Publisher
- Frontiers Research Foundation
- Number of pages
- 12
- Grant note
- R01AG000618 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG00618 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Wallace II. Coulter Foundation (Andres Kriete)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000209173000136
- Scopus ID
- 2-s2.0-84866409979
- Other Identifier
- 991019168899104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology