Journal article
Theoretical and experimental analysis of right ventricular bypass and univentricular circulatory support
IEEE transactions on biomedical engineering, v 37(2), pp 121-127
Feb 1990
PMID: 2312136
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The dynamic coupling between cardiac pump events and vascular arterial-venous factors that regulate the rate of blood flow around the circulation is examined. A series of experiments was designed to test the feasibility of maintaining vascular and pulmonary function in the absence of the right heart and to characterize the physiologic and hemodynamic consequence of such an exclusion. Theoretical analysis of the cardiovascular system (excluding neuro-humoral factors), using both lumped time invariant and distributed compartmental mathematical equivalent representations, demonstrated that a change in cardiac output has an inverse-linear effect on venous and direct-linear effect on arterial pressure. A single blood pump, in a form of a mechanical substitute for the biologic left heart, alone can support the circulation. Cardiac output reserve is limited (50% of normal) because of the rapidly diminishing pulmonary venous pressure as outflow is increased, irrespective of the pump's specific characteristics.< >
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Details
- Title
- Theoretical and experimental analysis of right ventricular bypass and univentricular circulatory support
- Creators
- J.Y Kresh - Dept. of Cardiothoracic Surg., Hahnemann Univ., Philadelphia, PA, USAS.K Brockman - Dept. of Cardiothoracic Surg., Hahnemann Univ., Philadelphia, PA, USAA Noordergraaf
- Publication Details
- IEEE transactions on biomedical engineering, v 37(2), pp 121-127
- Publisher
- IEEE
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1990CR26100002
- Scopus ID
- 2-s2.0-0025388873
- Other Identifier
- 991014878093304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical