Journal article
Theoretical description of the spatial dependence of sickle hemoglobin polymerization
Biophysical journal, v 58(3), pp 695-703
01 Jan 1990
PMID: 2207259
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have generalized the double nucleation mechanism to describe the spatial dependence of the radial growth of polymer domains of sickle hemoglobin. Although this extended model requires the consideration of effects such as monomer diffusion, which are irrelevant to a spatially uniform description, no new adjustable parameters are required because diffusion constants are known independently. We find that monomer diffusion into the growing domain can keep the net unpolymerized monomer concentration approximately constant, and in that limit we present an analytic solution of the model. The model provides a new means of determining the rate of polymer growth.
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Details
- Title
- Theoretical description of the spatial dependence of sickle hemoglobin polymerization
- Creators
- Huan-Xiang Zhou - Drexel UniversityF Ferrone - Drexel University
- Publication Details
- Biophysical journal, v 58(3), pp 695-703
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:A1990DX50000012
- Scopus ID
- 2-s2.0-0025184482
- Other Identifier
- 991019173790604721
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- Web of Science research areas
- Biophysics