Journal article
Therapeutic Engineered Hydrogel Coatings Attenuate the Foreign Body Response in Submuscular Implants
Annals of plastic surgery, v 80(6), pp S410-S417
01 Jun 2018
PMID: 29746273
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Biomedical devices are implanted into mammalian soft tissues to improve, monitor, or restore form or function. The utility of these implants is limited by the subsequent foreign body response (FBR), beginning with inflammation and terminating in a collagen envelope around the device, known as the capsule. This capsule then can contract and distort the shape of the device or limit its effectiveness in interacting with the surrounding host tissues. In the current study, we investigated the effect of therapeutic collagencoated silicone discs in a rat model of the FBR. Methods: A 3-dimensional printed mold was used to fabricate collagen-coated silicone discs incorporating 3 therapeutic agents: colchicine, a function-blocking antibody against interleukin 8 (IL-8) receptor B, and a powerful anti-inflammatory steroid, dexamethasone. Discs were implanted submuscularly into a wellcharacterized rat model of the FBR and evaluated for inflammatory response, fibrotic development, and cytokine release. Results: Coated silicone discs exhibited reduced collagen deposition and little to no foreign body giant cells at the host-silicone interface when compared with the silicone-only group. Therapeutic hydrogels demonstrate a significant decrease in cellular infiltration into the coatings over the 2-week time point in contrast to therapeutic-free hydrogel coatings. Cytokine analysis revealed significant differences between therapeutic-free and therapeutic-containing coatings when compared with silicone-only controls. Levels of IL-1 beta, IL-6, monocyte chemotactic protein 1, and macrophage inflammatory protein 3a were affected 48 hours after implantation, while differences in IL-18, growthregulated oncogene/keratinocyte chemoattractant, and macrophage inflammatory protein 3a were observed 1 week after implantation. Conclusions: By utilizing the host's innate immune response, our engineered hydrogel coatings delivered therapeutic moieties directly to the implant microenvironment, thus delaying the FBR up to 2 weeks.
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Details
- Title
- Therapeutic Engineered Hydrogel Coatings Attenuate the Foreign Body Response in Submuscular Implants
- Creators
- Katrina A. Harmon - University of South CarolinaBrooks A. Lane - University of South CarolinaRachel E. Boone - University of South CarolinaAshkan Afshari - University of South CarolinaHenrik O. Berdel - University of KentuckyMichael J. Yost - Medical University of South CarolinaRichard L. Goodwin - University of South CarolinaHarold I. Friedman - University of South CarolinaJohn F. Eberth - University of South Carolina
- Publication Details
- Annals of plastic surgery, v 80(6), pp S410-S417
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- Integra Life Sciences through the Southeastern Society of Plastic and Reconstructive Surgery, Richland Memorial Hospital Research and Education Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000473115400020
- Scopus ID
- 2-s2.0-85074238377
- Other Identifier
- 991021902595604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery