Journal article
Therapeutic Strategies Targeting Respiratory Recovery after Spinal Cord Injury: From Preclinical Development to Clinical Translation
Cells (Basel, Switzerland), v 12(11), 1519
31 May 2023
PMID: 37296640
Abstract
High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory dysfunction. Patients living with such conditions often rely on ventilatory assistance to survive, and even those that can be weaned continue to suffer life-threatening impairments. There is currently no treatment for SCI that is capable of providing complete recovery of diaphragm activity and respiratory function. The diaphragm is the main inspiratory muscle, and its activity is controlled by phrenic motoneurons (phMNs) located in the cervical (C3-C5) spinal cord. Preserving and/or restoring phMN activity following a high SCI is essential for achieving voluntary control of breathing. In this review, we will highlight (1) the current knowledge of inflammatory and spontaneous pro-regenerative processes occurring after SCI, (2) key therapeutics developed to date, and (3) how these can be harnessed to drive respiratory recovery following SCIs. These therapeutic approaches are typically first developed and tested in relevant preclinical models, with some of them having been translated into clinical studies. A better understanding of inflammatory and pro-regenerative processes, as well as how they can be therapeutically manipulated, will be the key to achieving optimal functional recovery following SCIs.
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Details
- Title
- Therapeutic Strategies Targeting Respiratory Recovery after Spinal Cord Injury: From Preclinical Development to Clinical Translation
- Creators
- Pauline Michel-Flutot - Univ Paris Saclay, END ICAP, UVSQ, Inserm, F-78000 Versailles, FranceMichael A. Lane - Drexel UniversityAngelo C. Lepore - Thomas Jefferson UniversityStephane Vinit - Univ Paris Saclay, END ICAP, UVSQ, Inserm, F-78000 Versailles, France
- Publication Details
- Cells (Basel, Switzerland), v 12(11), 1519
- Publisher
- MDPI
- Number of pages
- 20
- Grant note
- 733020 / Craig H. Neilsen Foundation 733020 / H2020 Societal Challenges Programme; Horizon 2020; European Union (EU) R01NS079702; R01NS104291 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm) Wings for Life Yant Family Spinal Cord Regeneration Fund Chancellerie des Universites de Paris Universite de Versailles Saint-Quentin-en-Yvelines R01-NS079702; R01-NS110385; R01-NS104291 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 4100094298 / Pennsylvania Department of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001005006400001
- Scopus ID
- 2-s2.0-85161473249
- Other Identifier
- 991022207161304721