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Journal article
Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia
Brain sciences, v 11(8), p1081
01 Aug 2021
PMID: 34439700
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mutations of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia. Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with toxic gain-of-function properties. With each of these two factors potentially relevant to disease etiology, the present article discusses possible therapeutic strategies that may ameliorate symptoms in patients suffering from SPAST-based Hereditary Spastic Paraplegia, which is usually termed SPG4-HSP.
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Details
- Title
- Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia
- Creators
- Neha Mohan - Drexel UniversityLiang Qiang - Drexel UniversityGerardo Morfini - University of Illinois at ChicagoPeter W. Baas - Drexel University
- Publication Details
- Brain sciences, v 11(8), p1081
- Publisher
- Mdpi
- Number of pages
- 9
- Grant note
- Spastic Paraplegia Foundation R01NS118177; R01NS115977 / NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:000688821200001
- Scopus ID
- 2-s2.0-85113405696
- Other Identifier
- 991019168068304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences