Journal article
Therapeutic phenytoin levels with tube feeding: New techniques
Journal of epilepsy, v 10(1), pp 22-25
1997
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A therapeutic serum level of phenytoin (PHT) is difficult to achieve in patients who receive enteral tube feeding. In four patients, PHT capsules were dissolved in 250 ml warm water and cooled to body temperature before being administered. A therapeutic serum level of PHT was maintained in all four patients. Another group of three patients received PHT suspension, at an interval of 8 h, with water at room temperature. Again serum PHT levels were maintained in the therapeutic range in all three patients. The present preliminary study indicates that bioavailability of PHT is increased by dissolution in water in patients receiving chronic enteral tube feeding. There is a need for further investigation of the kinetics of absorption of PHT and other antiepileptic drugs in patients receiving enteral tube feeding.
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Details
- Title
- Therapeutic phenytoin levels with tube feeding: New techniques
- Creators
- Pratap M. YagnikPaul L. SchraederKatherine O'Hara
- Publication Details
- Journal of epilepsy, v 10(1), pp 22-25
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1997WP35400006
- Scopus ID
- 2-s2.0-0030959583
- Other Identifier
- 991019339693104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology