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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury
Neuropharmacology, v 145(Pt B), pp 153-159
Feb 2019
PMID: 29933010
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injury. Advancements in acute neurosurgical interventions and neurocritical care have improved and led to a decrease in mortality rates over the past decades. However, survivors are left with life-long behavioral deficits underscoring the need to better define the cellular mechanisms underlying these functional changes. A better understanding of these mechanisms some of which begin in the acute post-traumatic period may likely lead to targeted treatment strategies. Key considerations in designing pre-clinical experiments to test therapeutic strategies in pediatric TBI include the use of age-appropriate and pathologically-relevant models, functional outcomes that are tested as animals age into adolescence and beyond, sex as a biological variable and the recognition that doses and dosing strategies that have been demonstrated to be effective in animal models of adult TBI may not be effective in the developing brain.
This article is part of the Special Issue entitled “Novel Treatments for Traumatic Brain Injury”.
•Pediatric TBI is a leading cause of morbidity in children below the age of 14.•As brain-injured children age into adulthood, they exhibit multiple cognitive and behavioral deficits.•The cellular pathology of brain injury in children includes axonal injury, neurodegeneration and inflammation.•Pleiotropic agents may be better suited to treat pediatric TBI.•Age, sex, drug pharmacokinetics and long-term behavioral measures need to be incorporated into the study design.
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Details
- Title
- Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury
- Creators
- Jimmy W. Huh - Children's Hospital of PhiladelphiaRamesh Raghupathi - Drexel University
- Publication Details
- Neuropharmacology, v 145(Pt B), pp 153-159
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000454967100004
- Scopus ID
- 2-s2.0-85058440167
- Other Identifier
- 991019167932104721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy