Journal article
Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease
Discovery medicine, Vol.7(39)
Aug 2007
PMID: 18093473
Abstract
Alzheimer's disease (AD) is a progressive and degenerative disorder pathophysiologically characterized by the accumulation of beta-amyloid peptides (A-beta) in the brain. A-beta is indicated to be the primary agent in the pathogenesis of AD. A-beta is generated from the amyloid precursor protein (APP) via two proteolytic enzymes, beta- and gamma-secretases. Alpha-secretase conducts an alternative proteolytic cleavage that prevents A-beta production and accumulation. Elevating levels of alpha-secretase cleavage, therefore, is a potential therapeutic strategy to treat AD.
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Details
- Title
- Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease
- Creators
- Can Zhang - Drexel UniversityAleister J Saunders
- Publication Details
- Discovery medicine, Vol.7(39)
- Grant note
- R01 NS057295 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Identifiers
- 991021448179004721