Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Therapeutic targets and nanomaterial-based therapies for mitigation of secondary injury after spinal cord injury
Nanomedicine (London, England), v 16(22), pp 2013-2028
01 Sep 2021
PMID: 34402308
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury (SCI) and the resulting neurological trauma commonly result in complete or incomplete neurological dysfunction and there are few effective treatments for primary SCI. However, the following secondary SCI, including the changes of microvasculature, inflammatory response and oxidative stress around the injury site, may provide promising therapeutic targets. The advances of nanomaterials hold promise for delivering therapeutics to alleviate secondary SCI and promote functional recovery. In this review, we highlight recent achievements of nanomaterial-based therapy, specifically targeting blood-spinal cord barrier disruption, mitigation of the inflammatory response and lightening of oxidative stress after spinal cord injury.
Metrics
Details
- Title
- Therapeutic targets and nanomaterial-based therapies for mitigation of secondary injury after spinal cord injury
- Creators
- Jun Gao - Clemson UniversityMinkyung Khang - Clemson UniversityZhen Liao - Clemson UniversityMegan Detloff - Drexel UniversityJeoung Soo Lee - Clemson University
- Publication Details
- Nanomedicine (London, England), v 16(22), pp 2013-2028
- Publisher
- Future Medicine Ltd
- Number of pages
- 16
- Grant note
- 5R01 NS111037-02 / National Institute of Neurological Disorders and Strokes (NINDS) of the NIH 5P20GM103444-07 / National Institute of General Medical Sciences (NIGMS) of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SCBioCRAFT)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000685258900001
- Scopus ID
- 2-s2.0-85114320606
- Other Identifier
- 991019169629804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Nanoscience & Nanotechnology