Journal article
Therapy of penicillin-resistant pneumococcal meningitis
Zentralblatt für Bakteriologie, v 282(1)
1995
PMID: 7734832
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antimicrobial therapy of pneumococcal meningitis has been altered in recent years based on changes in pneumococcal susceptibility patterns, with emergence of strains that are either relatively or highly resistant to penicillin G (minimal inhibitory concentrations of 0.1-1.0 μg/ml and ≥ 2 μg/ml respectively. In areas of the world where relatively penicillin-resistant strains of
Streptococcus pneumoniae are present, the third generation cephalosporins (either cefotaxime or ceftriaxone) should be used as empiric therapy, and for highly penicillinresistant pneumococcal strains, vancomycin (with or without rifampin) is recommended. It is imperative that susceptibility testing be performed on all cerebrospinal fluid pneumococcal isolates to guide the choice of antimicrobial therapy. Vaccination recommendations with the 23-valent pneumococcal vaccine should also be strictly enforced for use in appropriate populations that are at increased risk of pneumococcal infections.
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Details
- Title
- Therapy of penicillin-resistant pneumococcal meningitis
- Creators
- Mary T. Schwartz - Drexel UniversityAllan R. Tunkel - Drexel University
- Publication Details
- Zentralblatt für Bakteriologie, v 282(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:A1995QE01300003
- Scopus ID
- 2-s2.0-0029195314
- Other Identifier
- 991019346718104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Virology