Journal article
Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model
Journal of the Chinese Chemical Society (Taipei), v 62(1), pp 21-25
01 Jan 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this work, we present a kinetic analysis for protein aggregation using the kinetic Ising model, which serves as a new application of a previously proposed model [Liang et al., J. Chin. Chem. Soc. 2003, 50, 335]. Considering protein as a single spin unit, we map two states of a unit to the aggregation-prone (AP) and the fibril (F) states. This work shows that the model can successfully capture the nucleation-growth features of protein aggregation from experiments, which offers thermodynamic interpretations of aggregation properties, such as lag-time and fibril stability.
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Details
- Title
- Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model
- Creators
- Min-Yeh Tsai - National Yang Ming Chiao Tung UniversityJian-Min Yuan - Drexel UniversitySheng-Hsien Lin - National Yang Ming Chiao Tung University
- Publication Details
- Journal of the Chinese Chemical Society (Taipei), v 62(1), pp 21-25
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- 102-2811-M-009-070 / Ministry of Science and Technology (MOST), Taiwan ROC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000348005400004
- Scopus ID
- 2-s2.0-84921946723
- Other Identifier
- 991019168721304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary