Journal article
Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals
European spine journal, v 25(12), pp 4140-4154
01 Dec 2016
PMID: 27704284
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Based on the structural anatomy, loading condition and range of motion (ROM), no quadruped animal has been shown to accurately mimic the structure and biomechanical function of the human spine. The objective of this study is to quantify the thoracic vertebrae geometry of the kangaroo, and compare with adult human, pig, sheep, and deer.
The thoracic vertebrae (T1-T12) from whole body CT scans of ten juvenile kangaroos (ages 11-14 months) were digitally reconstructed and geometric dimensions of the vertebral bodies, endplates, pedicles, spinal canal, processes, facets and intervertebral discs were recorded. Similar data available in the literature on the adult human, pig, sheep, and deer were compared to the kangaroo. A non-parametric trend analysis was performed.
Thoracic vertebral dimensions of the juvenile kangaroo were found to be generally smaller than those of the adult human and quadruped animals. The most significant (p < 0.001) correlations (Rho) found between the human and kangaroo were in vertebrae and endplate dimensions (0.951 ae Rho ae 0.963), pedicles (0.851 ae Rho ae 0.951), and inter-facet heights (0.891 ae Rho ae 0.967). The deer displayed the least similar trends across vertebral levels.
Similarities in thoracic spine vertebral geometry, particularly of the vertebrae, pedicles and facets may render the kangaroo a more clinically relevant human surrogate for testing spinal implants. The pseudo-biped kangaroo may also be a more suitable model for the human thoracic spine for simulating spine deformities, based on previously published similarities in biomechanical loading, posture and ROM.
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Details
- Title
- Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals
- Creators
- Sriram Balasubramanian - Drexel UniversityJames R. Peters - Drexel UniversityLucy F. Robinson - Drexel UniversityAnita Singh - Widener UniversityRichard W. Kent - University of Virginia
- Publication Details
- European spine journal, v 25(12), pp 4140-4154
- Publisher
- Springer Nature
- Number of pages
- 15
- Grant note
- Drexel University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000389265000035
- Scopus ID
- 2-s2.0-84990857110
- Other Identifier
- 991019167576804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Orthopedics