Journal article
Three-dimensional in vitro cancer models: a short review
Biofabrication, v 6(2), pp 022001/1-022001/9
01 Jun 2014
PMID: 24727833
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The re-creation of the tumor microenvironment including tumor-stromal interactions, cell-cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two-dimensional (2D) cell culture and animal models have been proven to be valid in some areas of explaining cancerous cell behavior and interpreting hypotheses of possible mechanisms. However, a well-defined three-dimensional (3D) in vitro cancer model, which mimics tumor structures found in vivo and allows cell-cell and cell-matrix interactions, has gained strong interest for a wide variety of diagnostic and therapeutic applications. This communication attempts to provide a representative overview of applying 3D in vitro biological model systems for cancer related studies. The review compares and comments on the differences in using 2D models, animal models and 3D in vitro models for cancer research. Recent technologies to construct and develop 3D in vitro cancer models are summarized in aspects of modeling design, fabrication technique and potential application to biology, pathogenesis study and drug testing. With the help of advanced engineering techniques, the development of a novel complex 3D in vitro cancer model system will provide a better opportunity to understand crucial cancer mechanisms and to develop new clinical therapies.
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Details
- Title
- Three-dimensional in vitro cancer models: a short review
- Creators
- Chengyang Wang - Drexel UniversityZhenyu Tang - Shanghai Advanced Research InstituteYu Zhao - Tsinghua UniversityRui Yao - Tsinghua UniversityLingsong Li - Shanghai Advanced Research InstituteWei Sun - Tsinghua University
- Publication Details
- Biofabrication, v 6(2), pp 022001/1-022001/9
- Publisher
- Iop Publishing Ltd
- Number of pages
- 9
- Grant note
- 2012AA020506 / National High Technology Research and Development Program of China (863); National High Technology Research and Development Program of China NSF-CMMI-1030520 / National Science Foundation; National Science Foundation (NSF) 51235006 / Chinese National Natural Science Foundation; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000337705000002
- Scopus ID
- 2-s2.0-84899513546
- Other Identifier
- 991019167690004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials