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Three doses of vitamin D on bone mineral density in older women: a pilot study (257.4)
Journal article   Open access   Peer reviewed

Three doses of vitamin D on bone mineral density in older women: a pilot study (257.4)

Liliana Pop, Deeptha Sukumar, Yvette Schlussel, Steve Schneider, Theodore Stahl, Christopher Gordon and Sue Shapses
The FASEB journal, v 28(S1), pn/a
Apr 2014
DOI: https://doi.org/10.1096/fasebj.28.1_supplement.257.4
url
https://doi.org/10.1063/1.4994089View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Reports show that higher doses of vitamin D (vitD) intake than the recommended have no beneficial effect on BMD. In addition, both aging and weight loss reduce BMD. Our goal here is to determine whether vitD affects bone over 1 year in postmenopausal women who were counseled for weight control. Design: Fifty‐eight obese/overweight women (age, 58 ± 6 years; body mass index, 30.1 ± 3.8 kg/m2, serum 25‐hydroxyvitamin D (25OHD), 27.1 ± 4.4 ng/ml), were randomly assigned to one of 3 doses of vitD (A, 600 IU/d; B, 2000 IU/d; C, 4000 IU/d) with 1.2 Ca g/d. We analyzed 25OHD, parathyroid hormone and BMD and strength parameters by dual energy x‐ray absorptiometry and peripheral quantitative computed tomography. Results: At 1 year, serum 25OHD levels differed between groups (p < 0.01) and increased to 30.4 ± 5.2, 35.8 ± 4.5 and 41.5 ± 6.9 ng/ml, in groups A, B and C, respectively. Weight change was similar between groups (‐3.0 ± 4.1%). There was no significant BMD changes from baseline at the hip, spine or radius, but there was a decrease (p < 0.05) for total volumetric bone mineral content (BMC) (‐0.9 ± 3.4%), trabecular BMD (‐1.3 ± 3.8%) and BMC (‐2.9 ± 9.9%). Also, vitD affected cortical thickness over time (p<0.05) showing a change of ‐0.07± 0.22, +0.02 ± 0.15 and +0.09 ± 0.21 mm, for groups A, B and C, respectively. In conclusion, the vitD dose‐response on serum 25OHD levels improves cortical thickness but does not affect BMD or strength parameters. Grant Funding Source: NIH‐AJ12161

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