Journal article
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
The New England journal of medicine, v 378(1), pp 11-21
04 Jan 2018
PMID: 29129157
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effect of endovascular thrombectomy that is performed more than 6 hours after the onset of ischemic stroke is uncertain. Patients with a clinical deficit that is disproportionately severe relative to the infarct volume may benefit from late thrombectomy.
We enrolled patients with occlusion of the intracranial internal carotid artery or proximal middle cerebral artery who had last been known to be well 6 to 24 hours earlier and who had a mismatch between the severity of the clinical deficit and the infarct volume, with mismatch criteria defined according to age (<80 years or ≥80 years). Patients were randomly assigned to thrombectomy plus standard care (the thrombectomy group) or to standard care alone (the control group). The coprimary end points were the mean score for disability on the utility-weighted modified Rankin scale (which ranges from 0 [death] to 10 [no symptoms or disability]) and the rate of functional independence (a score of 0, 1, or 2 on the modified Rankin scale, which ranges from 0 to 6, with higher scores indicating more severe disability) at 90 days.
A total of 206 patients were enrolled; 107 were assigned to the thrombectomy group and 99 to the control group. At 31 months, enrollment in the trial was stopped because of the results of a prespecified interim analysis. The mean score on the utility-weighted modified Rankin scale at 90 days was 5.5 in the thrombectomy group as compared with 3.4 in the control group (adjusted difference [Bayesian analysis], 2.0 points; 95% credible interval, 1.1 to 3.0; posterior probability of superiority, >0.999), and the rate of functional independence at 90 days was 49% in the thrombectomy group as compared with 13% in the control group (adjusted difference, 33 percentage points; 95% credible interval, 24 to 44; posterior probability of superiority, >0.999). The rate of symptomatic intracranial hemorrhage did not differ significantly between the two groups (6% in the thrombectomy group and 3% in the control group, P=0.50), nor did 90-day mortality (19% and 18%, respectively; P=1.00).
Among patients with acute stroke who had last been known to be well 6 to 24 hours earlier and who had a mismatch between clinical deficit and infarct, outcomes for disability at 90 days were better with thrombectomy plus standard care than with standard care alone. (Funded by Stryker Neurovascular; DAWN ClinicalTrials.gov number, NCT02142283 .).
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Details
- Title
- Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
- Creators
- Raul G NogueiraAshutosh P JadhavDiogo C HaussenAlain BonafeRonald F BudzikParita BhuvaDileep R Yavagal - Jackson Memorial HospitalMarc Ribo - Vall d'Hebron Hospital UniversitariChristophe Cognard - Université de ToulouseRicardo A HanelCathy A SilaAmeer E Hassan - Valley Baptist Medical CenterMonica Millan - Hospital Universitari Germans Trias i PujolElad I LevyPeter Mitchell - Royal Melbourne HospitalMichael Chen - Rush University Medical CenterJoey D EnglishQaisar A Shah - Abington Memorial HospitalFrank L SilverBrijesh P Mehta - Memorial Regional HospitalVitor M PereiraBlaise W BaxterMichael G AbrahamPedro Cardona - Bellvitge University HospitalErol Veznedaroglu - Drexel University, NeurosurgeryFrank R Hellinger - AdventHealth OrlandoLei Feng - Kaiser Permanente San Francisco Medical CenterJawad F Kirmani - University Health NetworkDemetrius K LopesBrian T JankowitzMichael R FrankelVincent Costalat - Hôpital Gui de ChauliacNirav A VoraAlbert J YooAmer M Malik - Jackson Memorial HospitalAnthony J FurlanMarta Rubiera - Vall d'Hebron Hospital UniversitariAmin Aghaebrahim - Baptist Medical Center JacksonvilleJean-Marc OlivotWondwossen G Tekle - Valley Baptist Medical CenterRyan ShieldsTodd Graves - Berry & AssociatesRoger J Lewis - Harbor–UCLA Medical CenterWade S Smith - University of California, San FranciscoDavid S Liebeskind - University of California Los AngelesJeffrey L SaverTudor G JovinDAWN Trial Investigators
- Publication Details
- The New England journal of medicine, v 378(1), pp 11-21
- Publisher
- New England Journal of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurosurgery
- Web of Science ID
- WOS:000419220500013
- Scopus ID
- 2-s2.0-85040348659
- Other Identifier
- 991021869210104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology