Journal article
Thymidine Phosphorylase Expression in B-cell Lymphomas and Its Significance A New Prognostic Marker?
Analytical and quantitative cytology and histology, v 35(6)
01 Dec 2013
PMID: 24617035
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE: To explore thymidine phosphorylase (TP) expression in B-cell lymphomas (BCLs). TP is expressed by tumor and stromal cells in a variety of cancers.
STUDY DESIGN: Paraffin-embedded tissues from follicular lymphomas, diffuse large BCLs (DLBCLs), and benign lymph nodes were studied using immunohistochemical staining with antibodies for TP and CD68. Prognostic markers were used to stain DLBCLs. We correlated TP expression in DLBCL indirectly with prognostic immunomarkers and directly with survival data.
RESULTS: TP expression in BCLs was noted in a subset of malignant B cells. TP expression in higher-grade lymphoma was identified in 66% of cases and 11% of lower-grade lymphomas. Macrophages/stromal cells demonstrated an intense cytoplasmic and/or nuclear staining pattern in both lymphoma and benign lymph nodes, confirmed by CD68 coexpression. Increased macrophage/stromal cells in higher-grade lymphomas are associated with enhanced TP expression in neoplastic B cells (observation only). Sixty-eight percent of TP-positive DLBCLs were of nongerminal center origin, indicating poorer prognosis.
CONCLUSION: TP is more likely expressed by malignant B cells in higher-grade lymphomas, and expression of TP possibly results from changes intrinsic to the tumor cells or interactions between microenvironment and tumor. TP positivity in DLBCL correlates with nongerminal center origin and worse outcome.
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Details
- Title
- Thymidine Phosphorylase Expression in B-cell Lymphomas and Its Significance A New Prognostic Marker?
- Creators
- Xingcao Nie - Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USAPeter M. Clifford - Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USARekha Bhat - Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USARebecca Heintzelman - Drexel UniversityMini Abraham - Sisters of Mercy Health SystemJ. Steve Hou - Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USA
- Publication Details
- Analytical and quantitative cytology and histology, v 35(6)
- Publisher
- Sci Printers & Publ Inc
- Number of pages
- 5
- Grant note
- Department of Pathology, DUCOM Department of Pathology, Drexel University College of Medicine (DUCOM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000341746300001
- Scopus ID
- 2-s2.0-84890607876
- Other Identifier
- 991019167770904721
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- Web of Science research areas
- Cell Biology