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Journal article
Thyroid and thyroxine effects on adrenoreceptors in relation to circadian activity
Pharmacology, biochemistry and behavior, v 46(1), pp 251-257
1993
PMID: 8255919
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Experiments were conducted to ascertain if changes in central adrenergic receptors could be associated with altered circadian activity patterns induced by thyroparathyroidecomy (TPX) and thyroxine. An initial experiment used TPX and sham-operated rats that had been exposed to dim red light for 7 months. The α and β receptor densities were compared in the suprachiasmatic nuclei (SCN), preoptic (PO), septum, and caudate-putamen. TPX animals showed significant reductions in
β
1 and
β
2 receptor densities in SCN and PO, and
α
1 densities in SCN, but no other changes A second experiment, lasting 4 months, examined the effects of thyroxine, which has been shown to reverse the period-shortening effects of TPX surgery. Thyroxine signicantly increased
β
1 receptors in both the SCN and ventromedial hypothalamus (VMH), the only regions that displayed significant reductions in TPXs during the second experiment. Increases of sevenfold and threefold were observed in the SCNs of TPXs and sham, respectively, but thyroxine's action in the VMH was limited to TPX animals, an affect that mimics thyroxine's antion on circadian activity rhythms.
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Details
- Title
- Thyroid and thyroxine effects on adrenoreceptors in relation to circadian activity
- Creators
- Janet M. Vessotskie - University of PennsylvaniaPaul McGonigle - University of PennsylvaniaRobert C. Molthen - University of PennsylvaniaDonald L. McEachron - University of Pennsylvania
- Publication Details
- Pharmacology, biochemistry and behavior, v 46(1), pp 251-257
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1993LY41300041
- Scopus ID
- 2-s2.0-0027359161
- Other Identifier
- 991019323774504721
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy