Journal article
Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice
Journal of orthopaedic research, v 42(1), pp 123-133
Jan 2024
PMID: 37337074
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study's objective was to investigate how contractile strength loss associated with a volumetric muscle loss (VML) injury affects the adjacent tibial bone structural and functional properties in male C57BL/6J mice. Mice were randomized into one of two experimental groups: VML-injured mice that were injured at age 12 weeks and aged to 20 weeks (8 weeks postinjury, VML) and 20-week-old age-matched uninjured mice (Uninjured-20). Tibial bone strength, mid-diaphysis cortical geometry, intrinsic material properties, and metaphyseal trabecular bone structure were assessed by three-point bending and microcomputed tomography (& mu;CT). The plantar flexor muscle group (gastrocnemius, soleus, plantaris) was analyzed for its functional capacities, that is, peak-isometric torque and peak-isokinetic power. VML-injured limbs had 25% less peak-isometric torque and 31% less peak-isokinetic power compared to those of Uninjured-20 mice (p < 0.001). Ultimate load, but not stiffness, was significantly less (10%) in tibias of VML-injured limbs compared to those from Uninjured-20 (p = 0.014). & mu;CT analyses showed cortical bone thickness was 6% less in tibias of VML-injured limbs compared to Uninjured-20 (p = 0.001). Importantly, tibial bone cross-section moment of inertia, the primary determinant of bone ultimate load, was 16% smaller in bones of VML-injured limbs compared to bones from Uninjured-20 (p = 0.046). Metaphyseal trabecular bone structure was also altered up to 23% in tibias of VML-injured limbs (p < 0.010). These changes in tibial bone structure and function after a VML injury occur during a natural maturation phase between the age of 12 and 20 weeks, as evidenced by Uninjured-20 mice having greater tibial bone size and strength compared to uninjured-aged 12-week mice.
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Details
- Title
- Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice
- Creators
- Albino G. Schifino - University of GeorgiaMarion A. Cooley - Augusta UniversityRoger X. X. Zhong - Augusta UniversityJunwon Heo - University of GeorgiaDaniel B. Hoffman - University of MinnesotaGordon L. Warren - Georgia State UniversitySarah M. Greising - University of MinnesotaJarrod A. Call - University of Georgia
- Publication Details
- Journal of orthopaedic research, v 42(1), pp 123-133
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- W81XWH-20-10885 / U.S. Department of Defense; United States Department of Defense S10OD025177 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:001017495500001
- Scopus ID
- 2-s2.0-85163388493
- Other Identifier
- 991022030046304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics