Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Time-of-day determines neuronal damage and mortality after cardiac arrest
Neurobiology of disease, v 36(2), pp 352-360
2009
PMID: 19664712
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ischemic events in humans are not evenly distributed across the day. To discriminate between temporal differences in the incidence of ischemia and susceptibility to ischemic events, we examined the outcome of global ischemia in a murine model at three time points during the day. Global cerebral ischemia in mice during the light phase impairs survival and exacerbates outcome compared to ischemia at other times of the day. Specifically, mice that underwent cardiac arrest during the light phase had greater numbers of degenerating neurons, greater microglial activation, and increased proinflammatory cytokine production in the ischemia-vulnerable hippocampus, as well as increased locomotor activity. Time-of-day differences were not altered by the melatonin receptor antagonist luzindole. Our results document that brain tissue displays endogenous fluctuations in susceptibility to ischemic damage and demonstrate that small differences in time of onset can significantly influence ischemic outcomes.
Metrics
Details
- Title
- Time-of-day determines neuronal damage and mortality after cardiac arrest
- Creators
- Zachary M. Weil - The Ohio State UniversityKate KarelinaAlan J. SuJacqueline M. BarkerGreg J. NormanNing ZhangA. Courtney DeVriesRandy J. Nelson
- Publication Details
- Neurobiology of disease, v 36(2), pp 352-360
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000271293000013
- Scopus ID
- 2-s2.0-70349781648
- Other Identifier
- 991020100204504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences