Journal article
Timeless protection of telomeres
Current genetics, v 62(4), pp 725-730
Nov 2016
PMID: 27068713
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The DNA replication machinery encounters problems at numerous genomic regions that are inherently difficult to replicate. These genomic regions include telomeres, which contain repetitive DNA and telomere-binding proteins. If not properly regulated, replication of such genomic regions can result in DNA damage, leading to genomic instability. Studies implicated a role of Timeless-related proteins at difficult-to-replicate genomic regions, including telomeres. However, how these proteins maintain telomeres was elusive. In a recent report, we described the role of Swi1, a Timeless-related protein, in telomere maintenance in fission yeast. We demonstrated that Swi1 is required for proper replication of repeat DNA sequences at telomeres. We also showed that Swi1-deficient cells utilize recombination-based ALT (alternative lengthening of telomeres)-like mechanisms to maintain telomeres in the absence of telomerase. Here, we highlight these findings and present additional data to discuss the role of Swi1
in telomere protection and ALT prevention.
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Details
- Title
- Timeless protection of telomeres
- Creators
- Mariana C Gadaleta - The Scripps Research Institute, La Jolla, CA, 92037, USAAlberto González-Medina - Universitat Pompeu Fabra, 08003, Barcelona, SpainEishi Noguchi - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA. enoguchi@drexelmed.edu
- Publication Details
- Current genetics, v 62(4), pp 725-730
- Publisher
- Springer Nature; United States
- Grant note
- R01 GM077604 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000385168400008
- Scopus ID
- 2-s2.0-84962877291
- Other Identifier
- 991014878151504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity