Journal article
Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
International journal of environmental research and public health, v 18(7), p3436
26 Mar 2021
PMID: 33810264
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as measured by cytokines, and PTB are inconsistent. Timing of cytokine measurement during pregnancy varies between studies and may contribute to inconsistent findings. We investigated the effects of timing on associations between 16 cervico-vaginal cytokines (Eotaxin, IL-10, IL-12p40, IL-17, IL-1RA, sIL-2rα, IL-1a, IL-1β, IL-2, IL-6, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, and VEGF) and PTB among 90 women throughout pregnancy. We used logistic regression to compare associations between concentrations of cervico-vaginal cytokines from periods in pregnancy and PTB. Trimester 1 cytokines had the strongest positive associations with PTB; for example, OR = 1.76 (95% confidence interval: 1.28, 2.42) for IL-6. Second and third trimester associations were weaker but largely positive. IL-1α was the only cytokine with a negative association (trimesters 2, 3 and overall pregnancy). Strong first trimester associations between cytokines and PTB suggest that measuring cytokines early in pregnancy may hold promise for early identification of PTB risk. Variations in cytokine measurement during pregnancy may contribute to inconsistencies among studies.
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Details
- Title
- Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
- Creators
- Miatta A Buxton - University of MichiganNoemi Meraz-Cruz - Universidad Nacional Autónoma de MéxicoBrisa N Sanchez - Drexel UniversityBetsy Foxman - University of MichiganMarisol Castillo-Castrejon - University of Oklahoma Health Sciences CenterMarie S O'Neill - University of MichiganFelipe Vadillo-Ortega - University of Michigan
- Publication Details
- International journal of environmental research and public health, v 18(7), p3436
- Publisher
- MDPI
- Grant note
- T42 OH008455-09 / NIOSH CDC HHS 5R25GM058641-18 / NIGMS NIH HHS R01 ES016932, R01 ES017022, T32 ES007062, and P30 ES017885 / NIEHS NIH HHS P30 ES017885 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000638498000001
- Scopus ID
- 2-s2.0-85103035499
- Other Identifier
- 991020099207904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health