Journal article
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells
Immunity (Cambridge, Mass.), v 41(3), pp 493-502
18 Sep 2014
PMID: 25238099
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 Asian macaques and African green monkeys with viruses that do or do not express Vpx and examined viral targeting of cells in vivo. While lack of Vpx expression affected viral dynamics in vivo, with decreased viral loads and infection of CD4⁺ T cells, Vpx expression had no detectable effect on infectivity of myeloid cells. Moreover, viral DNA was observed only within myeloid cells in tissues not massively depleted of CD4⁺ T cells. Myeloid cells containing viral DNA also showed evidence of T cell phagocytosis in vivo, suggesting that their viral DNA may be attributed to phagocytosis of SIV-infected T cells. These data suggest that myeloid cells are not a major source of SIV in vivo, irrespective of Vpx expression.
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Details
- Title
- Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells
- Creators
- Nina Calantone - National Institutes of HealthFan Wu - National Institutes of HealthZachary Klase - National Institutes of HealthClaire Deleage - LeidosMolly Perkins - National Institutes of HealthKenta Matsuda - National Institutes of HealthElizabeth A Thompson - Karolinska InstitutetAlexandra M Ortiz - National Institutes of HealthCarol L Vinton - National Institutes of HealthIlnour Ourmanov - National Institutes of HealthKarin Loré - Karolinska InstitutetDaniel C Douek - National Institutes of HealthJacob D Estes - LeidosVanessa M Hirsch - National Institutes of HealthJason M Brenchley - National Institutes of Health
- Publication Details
- Immunity (Cambridge, Mass.), v 41(3), pp 493-502
- Publisher
- Elsevier
- Grant note
- ZIA AI001029-07 / Intramural NIH HHS Z99 AI999999 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000342626500018
- Scopus ID
- 2-s2.0-84907996442
- Other Identifier
- 991021902506004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology