Journal article
Tocolytic Magnesium Sulfate Exposure and Risk of Cerebral Palsy among Children with Birth Weights Less Than 1,750 Grams
American journal of epidemiology, v 152(2), pp 120-124
15 Jul 2000
PMID: 10909948
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The authors examined the relation between intrapartum magnesium sulfate exposure and risk of cerebral palsy in a case-control study of low birth weight children designed to control for confounding by the clinical indications for magnesium in pregnancy. Case children (n = 97) included all singleton children with cerebral palsy who were born in 1985–1989 in Atlanta, Georgia with a birth weight less than 1,750 g and whose mothers had not had a hypertension-related disease during pregnancy. Control children (n = 110) were randomly selected from the infant survivors using identical selection criteria. Data on magnesium sulfate exposure, labor and delivery, and infant characteristics were abstracted from hospital records. The authors found no association between exposure to magnesium sulfate and cerebral palsy risk (odds ratio = 0.9; 95% confidence interval: 0.3, 2.6) either in all children or in subgroups with varying likelihoods for exposure to magnesium. However, the association did vary by birth weight, with a protective effect being seen in children born weighing less than 1,500 g and an elevated risk in children with birth weights of 1,500 g or more; all confidence intervals included 1.0 except for the combined <1,500 g group. Several ongoing randomized clinical trials of magnesium and cerebral palsy may shed more definitive light on this relation.
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Details
- Title
- Tocolytic Magnesium Sulfate Exposure and Risk of Cerebral Palsy among Children with Birth Weights Less Than 1,750 Grams
- Creators
- C. A. Boyle - Centers for Disease Control and PreventionM. Yeargin-Allsopp - Centers for Disease Control and PreventionD. E. Schendel - Centers for Disease Control and PreventionP. Holmgreen - Division of Birth Defects and Development Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GAG. P. Oakley - Emory University
- Publication Details
- American journal of epidemiology, v 152(2), pp 120-124
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000088211500004
- Scopus ID
- 2-s2.0-0034661886
- Other Identifier
- 991021463567304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health