Journal article
Tonic Resting State Hubness Supports High Gamma Activity Defined Verbal Memory Encoding Network in Epilepsy
NEUROSCIENCE, v 425
15 Jan 2020
PMID: 31786346
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High gamma activity (HGA) of verbal-memory encoding using invasive-electroencephalogram has laid the foundation for numerous studies testing the integrity of memory in diseased populations. Yet, the functional connectivity characteristics of networks subserving these memory linkages remains uncertain. By integrating this electrophysiological biomarker of memory encoding from IEEG with resting-state BOLD fluctuations, we estimated the segregation and hubness of HGA-memory regions in drug-resistant epilepsy patients and matched healthy controls. HGA-memory regions express distinctly different hubness compared to neighboring regions in health and in epilepsy, and this hubness was more relevant than segregation in predicting verbal memory encoding. The HGA-memory network comprised regions from both the cognitive control and primary processing networks, validating that effective verbal-memory encoding requires integrating brain functions, and is not dominated by a central cognitive core. Our results demonstrate a tonic intrinsic set of functional connectivity, which provides the necessary conditions for effective, phasic, task-dependent memory encoding. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
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Details
- Title
- Tonic Resting State Hubness Supports High Gamma Activity Defined Verbal Memory Encoding Network in Epilepsy
- Publication Details
- NEUROSCIENCE, v 425
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD; OXFORD
- Number of pages
- 0
- Grant note
- The authors thank the Epilepsy Monitoring Unit their help in data acquisition. We thank Dr. Dorian Pustina for his help with the machine learning strategy. The authors thank all the healthy controls and patients with epilepsy, whose data was used for this study. This work was supported, in part, by the DARPA Restoring Active Memory (RAM) program (Cooperative Agreement N66001-14-2-4032) to JK, YE, MS, AD, and JIT. JIT also acknowledges partial support from NIH 1R01NS112816-01. The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000504205300017
- Scopus ID
- 2-s2.0-85075985710
- Other Identifier
- 991021860782804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences