Journal article
Topical corticosteroids for the prevention of severe radiation dermatitis: a systematic review and meta-analysis
Supportive care in cancer, v 31(7), 382
01 Jul 2023
PMID: 37280403
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Radiation dermatitis (RD) is a frequently occurring adverse reaction during radiotherapy in cancer patients. While the use of topical corticosteroids (TCs) is common for the treatment of RD, its role in preventing severe reactions remains unclear. This systematic review and meta-analysis aim to evaluate the evidence on the use of TCs as prophylaxis of RD.
A systematic search was conducted using OVID MedLine, Embase, and Cochrane databases (between 1946 and 2023) to identify studies examining TC use in the prevention of severe RD. Statistical analysis was completed using RevMan 5.4 to calculate pooled effect sizes and 95% confidence intervals. Forest plots were then developed using a random effects model.
Ten RCTs with a total of 1041 patients met the inclusion criteria. Six studies reported on mometasone furoate (MF) and four studies reported on betamethasone. Both TCs were associated with a significant improvement in the prevention of moist desquamation [OR = 0.34, 95% CI [0.25, 0.47], p < 0.00001], but betamethasone was found to be more effective than MF [OR = 0.29, 95% CI [0.18, 0.46], p < 0.00001 and OR = 0.39, 95% CI [0.25, 0.61], p < 0.0001, respectively]. A similar finding was seen in reducing the development of grade 2 or higher RD according to the Radiation Therapy Oncology Group scale.
The current evidence supports the use of TCs in preventing severe reactions of RD. Both MF and betamethasone were found to be effective; however, betamethasone, a higher potency TC, is more effective despite MF being more commonly reported in literature.
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Details
- Title
- Topical corticosteroids for the prevention of severe radiation dermatitis: a systematic review and meta-analysis
- Creators
- Samantha Tam - University of TorontoGrace Zhou - University of TorontoMark Trombetta - Drexel UniversitySaverio Caini - Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network [ISPO], Florence, ItalyJulie Ryan Wolf - University of RochesterCorina van den Hurk - Netherlands Comprehensive Cancer OrganisationMara Beveridge - Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network [ISPO], Florence, ItalyHenry Lam - Sunnybrook Health Science CentrePierluigi Bonomo - Azienda Ospedaliero-Universitaria CareggiEdward Chow - University of TorontoTara Behroozian - McMaster University
- Publication Details
- Supportive care in cancer, v 31(7), 382
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:001002715400003
- Scopus ID
- 2-s2.0-85161049343
- Other Identifier
- 991022207172604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Health Care Sciences & Services
- Oncology
- Rehabilitation