Journal article
Total skin electron beam and total nodal irradiation of cutaneous T-cell lymphoma
International journal of radiation oncology, biology, physics, v 20(4), pp 809-813
1991
PMID: 2004959
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nineteen patients with cutaneous T-cell lymphoma (CTCL) limited to the skin and/or lymph nodes were treated at Hahnemann University with a combination of total skin electron beam and total nodal irradiation (TSEB + TNI). The patients were classified as Stage Ib (1 patient), Stage IIa (8 patients), Stage IIb (5 patients), and Stage IVa (5 patients). Treatment resulted in a complete response in 100% (
14
14
) of patients with Stage lb, IIa, and Ilb disease, and a CR in 60% (
3
5
) of patients with Stage IVa disease. The Stage Ib and IIa patients had an overall survival of 100% and a disease-free survival of 44% at 6 years. Four of the five patients with Stage IIb CTCL relapsed within 3 months after completing TSEB + TNI with an overall survival in the group of 40% at 5 years. The Stage IVa patients all relapsed within 7 months and died of their disease within 50 months of completing treatment. The acute effects of TSEB + TNI were well tolerated, but three patients developed second malignancy (lung, kidney and skin) and one patient developed myelodysplasia, possibly the result of radiotherapy.
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Details
- Title
- Total skin electron beam and total nodal irradiation of cutaneous T-cell lymphoma
- Creators
- Bizhan Micaily - Hahnemann University HospitalOdette Campbell - Hahnemann University HospitalCharles Moser - Hahnemann University HospitalEric C Vonderheid - Hahnemann University HospitalLuther W Brady - Hahnemann University Hospital
- Publication Details
- International journal of radiation oncology, biology, physics, v 20(4), pp 809-813
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:A1991FC80600025
- Scopus ID
- 2-s2.0-0025761725
- Other Identifier
- 991019184032204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging