Journal article
Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous t-cell lymphoma
International journal of radiation oncology, biology, physics, v 11(6), pp 1111-1115
1985
PMID: 3922928
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Conversely, a long-term CR occurred in only one of five patients with tumor-phase intracutaneous CTCL (Stage IIB) and in none of the 5 patients with histopathologically proven nodal involvement (Stage IVA). Radiotherapy was well tolerated with the major toxicity being vone marrow suppression. We conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.
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Details
- Title
- Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous t-cell lymphoma
- Creators
- Bizhan Micaily - Temple UniversityEric C. vonderheid - Temple UniversityLuther W. Brady - Temple UniversityCharles Andrews - Hahnemann University HospitalHahnemann Univ., Philadelphia, PA
- Publication Details
- International journal of radiation oncology, biology, physics, v 11(6), pp 1111-1115
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:A1985AJP7100006
- Scopus ID
- 2-s2.0-0021878407
- Other Identifier
- 991019184061504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging