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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Totopotensamides, Polyketide-Cyclic Peptide Hybrids from a Mollusk-Associated Bacterium Streptomyces sp
Journal of natural products (Washington, D.C.), v 75(4), pp 644-649
01 Apr 2012
PMID: 22439622
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Two new compounds, the peptide polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey's method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.
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Details
- Title
- Totopotensamides, Polyketide-Cyclic Peptide Hybrids from a Mollusk-Associated Bacterium Streptomyces sp
- Creators
- Zhenjian Lin - University of UtahMalem Flores - University of the Philippines SystemImelda Forteza - University of the Philippines SystemNiel M. Henriksen - University of UtahGisela P. Concepcion - University of the Philippines SystemGary Rosenberg - Drexel UniversityMargo G. Haygood - Oregon Health & Science UniversityBaldomero M. Olivera - University of UtahAlan R. Light - University of UtahThomas E. Cheatham - University of UtahEric W. Schmidt - University of Utah
- Publication Details
- Journal of natural products (Washington, D.C.), v 75(4), pp 644-649
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 6
- Grant note
- U01TW008163 / ICBG from Fogarty (NIH) U01TW008163 / FOGARTY INTERNATIONAL CENTER; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES); Malacology
- Web of Science ID
- WOS:000303220500019
- Scopus ID
- 2-s2.0-84860341355
- Other Identifier
- 991019168687604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy
- Plant Sciences