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Journal article
Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells
Tissue engineering. Part B, Reviews, v 20(4), pp 314-327
01 Aug 2014
PMID: 24044776
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Glioblastoma multiforme (GBM) tumors are one of the most deadly forms of human cancer and despite improved treatments, median survival time for the majority of patients is a dismal 12-15 months. A hallmark of these aggressive tumors is their unique ability to diffusively infiltrate normal brain tissue. To understand this behavior and successfully target the mechanisms underlying tumor progression, it is crucial to develop robust experimental ex vivo disease models. This review discusses current two-dimensional (2D) experimental models, as well as animal-based models used to examine GBM cell migration, including their advantages and disadvantages. Recent attempts to develop three-dimensional (3D) tissue engineering-inspired models and their utility in unraveling the role of microenvironment on tumor cell behaviors are also highlighted. Further, the use of 3D models to bridge the gap between 2D and animal models is explored. Finally, the broad utility of such models in the context of brain cancer research is examined.
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Details
- Title
- Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells
- Creators
- Shreyas S. Rao - The Ohio State UniversityJohn J. Lannutti - The Ohio State UniversityMariano S. Viapiano - Brigham and Women's HospitalAtom Sarkar - Geisinger Health SystemJessica O. Winter - The Ohio State University
- Publication Details
- Tissue engineering. Part B, Reviews, v 20(4), pp 314-327
- Publisher
- Mary Ann Liebert, Inc
- Number of pages
- 14
- Grant note
- Pelotonia Graduate Fellowship Women in Philanthropy, OSU CBET BME 0854015; EEC 0425626 / National Science Foundation; National Science Foundation (NSF) H.C. "Slip" Slider Professorship R01CA152065 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology; Neurosurgery
- Web of Science ID
- WOS:000340521800009
- Scopus ID
- 2-s2.0-84905578641
- Other Identifier
- 991021960651504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Cell & Tissue Engineering
- Cell Biology
- Engineering, Biomedical
- Materials Science, Biomaterials