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Tracheal Resection and Mucociliary Clearance
Journal article   Peer reviewed

Tracheal Resection and Mucociliary Clearance

Anthony Giordano and Douglas S. Holsclaw
Annals of otology, rhinology & laryngology, v 85(5), pp 631-639
Sep 1976
DOI: https://doi.org/10.1177/000348947608500512
PMID: 984656

Abstract

Mucociliary transport following tracheal resection and end-to-end anastomosis was evaluated in beagle dogs, using the movement of 99M TC labeled sodium pertechnetate solution as a marker. Preoperatively, mucociliary clearance was stable, but a three-fold decrease in tracheal mucus movement was found three days postoperatively. Clearance rates had returned to normal by 31 days postoperatively and remained stable over a ten week period of observation. By histological examination, normal ciliated epithelium was seen within six months following resection and anastomosis. Since up to 25% (4 cm or seven tracheal rings) of tracheal length was removed, significant longitudinal loss can take place without functional impairment of mucociliary clearance. Circumferential narrowing, however, was associated with a significant decrease in clearance.

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