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Journal article
Trajectory of Cognitive Decline After Incident Heart Failure Hospitalization: Findings From the REGARDS Study
Journal of the American Heart Association, v 13(17), 032986
03 Sep 2024
PMID: 39206730
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cognitive impairment is common among adults with heart failure (HF) and associated with poor outcomes. However, less is known about the trajectory of cognitive decline after a first HF hospitalization. We examined the rate of cognitive decline among adults with incident HF hospitalization compared with those without HF hospitalization.
The REGARDS (Reasons for Geographic and Racial Differences in Stroke) study is a prospective longitudinal study of 23 894 participants aged ≥45 years free of HF at baseline. HF hospitalization was expert adjudicated. Changes in global cognitive function (primary outcome) were assessed with the Six-Item Screener (range, 0-6). Secondary outcomes included change in Word List Learning (range, 0-30), Word List Delayed Recall (WLD; range, 0-10), and Animal Fluency Test (range, 0+). Segmented linear mixed-effects regression models were used. Over 5 years, mean scores across all 4 cognitive tests declined for all participants regardless of HF status. Those with incident HF hospitalization experienced faster declines in the Six-Item Screener versus those who were HF free (difference, -0.031 [95% CI, -0.047 to -0.016];
<0.001), a finding that persisted in fully adjusted models. Those with incident HF hospitalization did not experience faster declines in Word List Learning, Word List Delayed Recall, or Animal Fluency Test scores compared with those without HF hospitalization. Participants with hospitalization for HF with preserved, compared with reduced, ejection fraction had faster decline in Animal Fluency Test.
Global cognitive decline occurred faster among adults with incident HF hospitalization compared with those who remained free of HF hospitalization. This pattern was not seen for the other cognitive domains.
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Details
- Title
- Trajectory of Cognitive Decline After Incident Heart Failure Hospitalization: Findings From the REGARDS Study
- Creators
- Madeline R Sterling - Cornell UniversityJoanna Bryan Ringel - Cornell UniversityMonika M Safford - Cornell CollegeParag Goyal - Cornell UniversityYulia Khodneva - University of Alabama at BirminghamLeslie A McClure - Drexel University, Epidemiology and BiostatisticsRaegan W Durant - University of Alabama at BirminghamAlexandra E Jacob - University of Alabama at BirminghamEmily B Levitan - University of Alabama at Birmingham
- Publication Details
- Journal of the American Heart Association, v 13(17), 032986
- Grant note
- R01 HL165452 / NHLBI NIH HHS R01 HL169312 / NHLBI NIH HHS R01 HL080477 / NHLBI NIH HHS K23 HL150160 / NHLBI NIH HHS U01 NS041588 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001304211600044
- Scopus ID
- 2-s2.0-85203203764
- Other Identifier
- 991022025737504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems