Journal article
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection
Nature medicine, v 14(3), pp 266-274
01 Mar 2008
PMID: 18311149
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The persistence of central memory CD4(+) T cells (T-CM cells) is a major correlate of immunological protection in HIV/AIDS, as the rate of T-CM cell decline predicts HIV disease progression. In this study, we show that T-CM cells and effector memory CD4(+) T cells (T-EM cells) from HIV+ elite controller (EC) subjects are less susceptible to Fas-mediated apoptosis and persist longer after multiple rounds of T cell receptor triggering when compared to T-CM and T-EM cells from aviremic successfully treated (ST) subjects or from HIV- donors. We show that persistence of T-CM cells from EC subjects is a direct consequence of inactivation of the FOXO3a pathway. Silencing the transcriptionally active form of FOXO3a by small interfering RNA or by introducing a FOXO3a dominant-negative form (FOXO3a Nt) extended the long-term survival of T-CM cells from ST subjects to a length of time similar to that of T-CM cells from EC subjects. The crucial role of FOXO3a in the survival of memory cells will help shed light on the underlying immunological mechanisms that control viral replication in EC subjects.
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Details
- Title
- Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection
- Creators
- Julien van Grevenynghe - Université de MontréalFrancesco A. Procopio - Université de MontréalZhong He - Université de MontréalNicolas Chomont - Université de MontréalCatherine Riou - Université de MontréalYuwei Zhang - Université de MontréalSylvain Gimmig - Université de MontréalGenevieve Boucher - Université de MontréalPeter Wilkinson - Université de MontréalYu Shi - Université de MontréalBader Yassine-Diab - Université de MontréalElias A. Said - Université de MontréalLydie Trautmann - Université de MontréalMohamed El Far - Université de MontréalRobert S. Balderas - BD Biosciences (United States)Mohamed-Rachid Boulassel - McGill UniversityJean-Pierre Routy - McGill UniversityElias K. Haddad - Université de MontréalRafick-Pierre Sekaly - McGill University
- Publication Details
- Nature medicine, v 14(3), pp 266-274
- Publisher
- Springer Nature
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000253815700032
- Scopus ID
- 2-s2.0-40449085117
- Other Identifier
- 991020099462304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental