Journal article
Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts
The Journal of heart and lung transplantation, v 26(12), pp 1255-1263
01 Dec 2007
PMID: 18096476
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Profiling mRNA levels of I I informative genes expressed by circulating immune effector cells identifies cardiac allograft recipients at low risk for current moderate-severe acute cellular rejection (ACR).
Methods: We conducted a nested case-control study of 104 cardiac allograft recipients to investigate the association of transcriptional profiles of blood samples with either a future rejection episode within 12 weeks of a baseline clinical sample or persistent histologic quiescence for the same time period.
Results: The transcription profile yielded a score (0 to 40 scale) of 27.4 +/- 6.3 for future rejectors (n = 39) and 23.9 +/- 7.1 for controls (n = 65) (p = 0.01). In patients who were <= 180 days post-transplant, the gene expression score was 28.4 +/- 4.9 for rejectors (n = 28) and 22.4 +/- 7.5 for controls (n = 48) (p < 0.001). In this period, no samples from patients who went on to reject within 12 weeks had gene expression scores of <20. Differential expression of the gene IL1R2 was significantly associated with future events. Of 33 additional genes profiled, 5 supported corticosteroid-sensitive constituents (lL1R2 and FLT3), whereas 6 supported T-cell activation (PDCD1).
Conclusions: These data suggest that pathways regulating T-cell homeostasis and corticosteroid sensitivity are associated with future ACR in cardiac allografts and suggest that these signals are evident before histologically detectable rejection. J Heart Lung Transplant 2007;26:1255-63. Copyright (c) 2007 by the International Society for Heart and Lung Transplantation.
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Details
- Title
- Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts
- Creators
- Mandeep R. Mehra - University of Maryland, BaltimoreJon A. Kobashigawa - Center of Mathematical Sciences, Zhejiang UniversityMario C. Deng - Columbia UniversityKenneth C. Fang - XDx, Inc., Brisbane, CaliforniaTod M. Klingler - XDx, Inc., Brisbane, CaliforniaPreeti G. Lal - XDx, Inc., Brisbane, CaliforniaSteven Rosenberg - XDx, Inc., Brisbane, CaliforniaPatricia A. Uber - University of Maryland, BaltimoreRandall C. Starling - Cleveland ClinicSrinivas Murali - Allegheny General HospitalDaniel F. Pauly - University of FloridaRussell Dedrick - XDx, Inc., Brisbane, CaliforniaMichael G. Walker - XDx, Inc., Brisbane, CaliforniaAdriana Zeevi - University of PittsburghHoward J. Eisen - Drexel UniversityCargo Investigators
- Publication Details
- The Journal of heart and lung transplantation, v 26(12), pp 1255-1263
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000251993500005
- Scopus ID
- 2-s2.0-37249046582
- Other Identifier
- 991019167586804721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery
- Transplantation