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Journal article
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Nature communications, v 11(1), pp 3358-3358
03 Jul 2020
PMID: 32620757
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data from healthy subjects. For each of the six investigated disorders, we show that spatial patterns of cortical anatomy changes in youth are correlated with cortical spatial expression of CNV genes in neurotypical adults. By transforming normative bulk-tissue cortical expression data into cell-type expression maps, we link anatomical change maps in each analysed disorder to specific cell classes as well as the CNV-region genes they express. Our findings reveal organizing principles that regulate the mapping of genetic risks onto regional brain changes in neurogenetic disorders. Our findings will enable screening for candidate molecular mechanisms from readily available neuroimaging data.
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Details
- Title
- Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
- Creators
- Jakob Seidlitz - University of CambridgeAjay Nadig - National Institute of Mental HealthSiyuan Liu - National Institute of Mental HealthRichard A I Bethlehem - University of CambridgePetra E Vértes - University of CambridgeSarah E Morgan - University of CambridgeFrantišek Váša - University of CambridgeRafael Romero-Garcia - University of CambridgeFrançois M Lalonde - Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD, USALiv S Clasen - National Institute of Mental HealthJonathan D Blumenthal - National Institute of Mental HealthCasey Paquola - Montreal Neurological Institute and HospitalBoris Bernhardt - Montreal Neurological Institute and HospitalKonrad Wagstyl - University of CambridgeDamon Polioudakis - Semel Institute for Neuroscience and Human BehaviorLuis de la Torre-Ubieta - Semel Institute for Neuroscience and Human BehaviorDaniel H Geschwind - Semel Institute for Neuroscience and Human BehaviorJoan C Han - Le Bonheur Children's HospitalNancy R Lee - Drexel UniversityDeclan G Murphy - King's College LondonEdward T Bullmore - University of CambridgeArmin Raznahan - National Institute of Mental Health
- Publication Details
- Nature communications, v 11(1), pp 3358-3358
- Publisher
- Springer Nature
- Grant note
- MC_G0802534 / Medical Research Council MR/K020706/1 / Medical Research Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000546623500058
- Scopus ID
- 2-s2.0-85087425878
- Other Identifier
- 991019167971204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences